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KMID : 1094020160330060325
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Journal of Veterinary Clinics
2016 Volume.33 No. 6 p.325 ~ p.331
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The Antinociceptive Effects of Epidural Tramadol with Bupivacaine in Beagle Dogs
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Park Ji-Young
Kim Se-Hui
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Abstract
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This study investigated the antinociceptive effect of epidural tramadol with bupivacaine in 36 healthy Beagledogs. The dogs were divided into 6 groups; 1) C (control), 2) B (0.5% bupivacaine 0.1 mL/kg), 3) BT0.5 (0.5%bupivacaine 0.1 mL/kg + tramadol 0.5 mg/kg), 4) BT1 (0.5% bupivacaine 0.1 mL/kg + tramadol 1 mg/kg), 5) BT2 (0.5%bupivacaine 0.1 mL/kg + tramadol 2 mg/kg), 6) BT3 (0.5% bupivacaine 0.1 mL/kg + tramadol 3 mg/kg). The epiduralinjection was performed under isoflurane inhalation, after then, nociceptive block and motor block scores were assessedwith physiologic parameters (HR, RR, RT, MAP). BT groups showed significantly longer antinociceptive time thanC and B, while motor block time of BT groups were not different from B except BT3. Durations of total nociceptiveblock of BT2 (60.83 ± 19.08 min) and BT3 (74.17 ± 8.61 min) were significantly longer than those of BT0.5(33.33 ± 8.76 min) and BT1 (37.50 ± 19.43 min), but there was no significant difference between BT2 and BT3. Durations of total motor block in all groups were less than 20 minutes although that of BT3 was significantly longerthan B. There were no significant differences in HR, RR, RT, MAP among groups. Consequently, epidural administrationof tramadol (2 mg/kg) with 0.5% bupivacaine (0.1 mL/kg) can be used safely and effectively in dogs.
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KEYWORD
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epidural anesthesia, tramadol-bupivacaine, nociceptive block, motor block, dog
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